MIKAMUN is the universal multicomponent mycotoxin adsorbent having properties of suppression the growth of mold, hepatoprotection and improving the metabolism. “MIKAMUN” strongly binds mycotoxins in feeds and kills most harmful fungi from the genera Aspergillus, Fusarium, Stachybotrys and Dendrodochium. “MIKAMUN” protects the liver by eliminating the root cause of her injuries – mycotoxins and their producers. At the same time, “MIKAMUN” improves liver function and its ability to transform mycotoxins. High liver activity positively affects the functioning of all the organs, which eventually leads to higher animal productivity, improved product quality, reduced morbidity and mortality in adult and young animals.
The main difficulties in the industrial animal husbandry
The body of the cow is a modern plant, equipped with everything necessary for the production of milk – one of the most valuable food products. Milk provides the calf with all the necessary nutrients. It contains valuable proteins, amino acids, fats, carbohydrates, minerals, vitamins and antioxidants. On the one hand, the modern breed cows have almost reached the maximum genetic potential of productivity. On the other hand, the organism of highly productive cows is much more susceptible to adverse factors of an environment, such as mycotoxins, negative energy balance of the diet, obesity, rumen acidosis, early lactation, stress, high nitrogen content in the feed, free radical oxidation. It is not surprising, because the more complex the mechanism, the more it breaks.
Ketogenic silage and rumen acidosis
The negative factors that can lead to pathological changes in the body of cattle include the ketogenic silage. In conditions of high humidity and low sugar concentration in the silage the bacteria of the genus Clostridium are actively developing. These microorganisms perform butyric acid fermentation, resulting in a silage becomes a characteristic putrid odor. Cow organism is unable to process all the formed butyric acid, whereby a large part (75%) is oxidized to form a 3-hydroxybutyric acid. It is importantly that the butyric acid is dangerous in all, even very low concentrations. At the same time, the more butyric acid is contained in silage, the more the body will suffer from the effects of 3-hydroxybutyric acid.
Ketoacidosis and “fat cow syndrome”
Ketoacidosis is a pathological condition of the body, which develops due to the increase in the blood concentration of ketone bodies, which include 3-hydroxybutyric acid and acetoacetic. For about 20 years, ketoacidosis is considered to be the most dangerous non-contagious disease of cattle, even taking into account the harm that cause serious diseases such as milk fever, as well as rumen acidosis. Most often ketoacidosis appear 3-6 weeks after calving.
“Fat cow syndrome” begins in cows shortly before calving and continues for some time after it, when the body actively uses fat stores, and food is often deficient in metabolizable energy. The concentration of the fatty acid increases in the blood, most of which are not used to produce energy, and deposited in the liver, causing its obesity. Liver, weakened in this way, do not have time to synthesize sufficient amounts of glucose, which necessary for an organism during this difficult period. As a by-product of fatty acid oxidation, ketone bodies are produced which can be detected in the blood one week after calving.
As a result of the deterioration of the liver is a weakening of the immune system, increasing susceptibility to infectious agents and mycotoxins. Due to the development of immunosuppressive status in ketoacidosis and “fatty liver syndrome” frequently observed complications in the form of infectious diseases such as metritis, mastitis and pneumonia, which in normal conditions are not so dangerous.
The multifunctional feed additive MIKAMUN combining properties ща hepatoprotectок and the adsorbent of mycotoxins, has been designed specifically for prevention of disorders which are most common in dairy cattle. The composition of this feed additive comprises adsorbent of mycotoxins, minerals, trace elements, selenium methionine, silicon, calcium, and vitamin E. Unlike most adsorbents that bind mycotoxins only in acidic environment “Mikamun” it works in both acidic and alkaline environment.
“MIKAMUN” contains silica in an amorphous state, which is easily absorbed by the body. Silicon – a ultramicroelements, ie nutrient which needs for the organism is calculated in micrograms, but without which a normal course of metabolism is not possible. Furthermore, amorphous silicon dioxide acts as an efficient adsorbent of mycotoxins, even hard to be adsorbed such as zearalenone and T-2 toxin and DON. The efficiency of adsorbent is reinforced by the presence of antioxidants and hepatoprotectors.
Probiotic Bacillus subtilis promotes the absorption of feed and detoxification of mycotoxins by the synthesis of hydrolytic enzymes and also exhibit antagonistic properties against the most toxigenic fungi genera Aspergillus, Fusarium, Stachybotrys and Dendrodochium. Probiotic Bacillus subtilis capable of strongly inhibit fungal sporulation, when synthesis of mycotoxins occurs. Thus, the probiotic strain destroys existing mycotoxins in the feed and does not give a new form.
Synthesized by the bacterium Bacillus subtilis organic acid and polypeptide antibiotics improve the condition of the natural intestinal flora and contribute to a more complete absorption of nutrients in the gastrointestinal tract of cattle.
Tocopherol, vitamin U, and sodium selenite protects cell membranes from peroxidation and the action of toxins. Vitamin E is considered to be the most powerful antioxidants known today. Protecting cell membranes, it supports energy metabolism at the level necessary to achieve maximum productivity and high quality of milk.
Methionine under the action of digestive tract microflora enzyme system reacts with sodium selenite, forming a selenomethionine that is not less important elements of the antioxidant system as vitamin E. In addition, methionine is one of the most efficient hepatoprotectors, which is extremely important to protect the liver and to prevent the formation of ketone bodies.
The activated calcium carbonate, which neutralizes the excessiveacidity helps to manage the problem of rumen acidosis. The calcium ions, which are easily absorbed by the body, are released in the process of neutralizing of acid. The contents of the rumen becomes slightly alkaline, that positively act on the availability of amorphous silicon.
Thus, the regular use of feed additive MIKAMUN helps to eliminate the following problems:
- mycotoxin contamination of feed;
- ketogenic silage;
- rumen acidosis;
- lack of calcium;
- deficiency of vitamin E and selenium;
- poor viability of calves;
- low milk production and poor quality of milk;
- the destruction of cell membranes by free radicals;
- poor digestibility
The feed additive “MIKAMUN” has a number of advantages compared to conventional mineral additives. First, complex effect of calcium carbonate and amorphous silicon; secondly, the synergism between methionine, vitamin E and selenium; thirdly, increase elasticity of blood vessels under the action of silicon; and fourthly, immunomodulatory effects and liver protection.